Endocrine Abstracts

Background: Anaplastic thyroid-carcinomas (ATC) and a subset of papillary (PTC) and follicular (FTC) thyroid carcinomas behave aggressively showing metastatic spread and radio-resistance. Both the PI3K and HIF pathways are associated with aggressiveness and metastasis in thyroid carcinoma.Aims: To assess if the PI3K/HIF pathways contribute to radio-resistance and assess the effect of PI3K/HIF inhibition on radio-sensitivity and metastatic behaviour of th...

Intratumoural hypoxia is associated with aggressive and metastatic phenotypes with poor prognosis. The transcription factor HIF-1α is a key regulator of hypoxia-mediated gene expression that is documented to promote tumour growth and metastasis in a wide range of cancers. However its role in the development of thyroid carcinomas is relatively unknown. We have previously shown that HIF-1α is highly active in a range of thyroid cancer cell lines with highest activity o...

Background: Intratumoural hypoxia is associated with an aggressive and metastatic phenotype and poor prognosis. The transcription factor Hypoxia-inducible Factor-1α (HIF-1α) is a key regulator of hypoxia, inducing the expression of genes which promote tumour cell survival, such as carbonic-anhydrase IX (CA-IX) playing a role in cell adhesion, pH regulation and dedifferentiation of the tumours. Here we investigated whether there is cross talk between the HIF-1 and Wnt...

The transcription factor HIF-1α regulates hypoxia-mediated gene expression which promotes tumour growth, metastasis and desensitisation to chemo-and radiotherapy. HIF-1 is functional in a range of thyroid-carcinoma cells and is regulated by hypoxia and the PI3K and MAPK-signalling pathways.We aimed to determine if HIF-1 and PI3K were important in the development of a metastatic phenotype and play a role in desensitisation to radiotherapy in thyroid ...